Brief, intense radiation and hormone therapy for very high-risk prostate cancer
As we’ve seen, brachy boost therapy seems to have the best oncological results for men with very high-risk prostate cancer. But brachy boost therapy entails 20-25 external beam radiation treatments...
View ArticleLower salvage radiation dose — are outcomes the same?
A large randomized clinical trial, SAKK 09/10, found that a salvage radiation dose of 64 Gy over 32 treatments had equivalent biochemical outcomes compared to 70 Gy over 35 treatments. They treated 350...
View ArticleExtending OS on initial ADT for men with mHSPC
Back in 1989, the SWOG 8494 trial first showed that adding an antiandrogen (flutamide) to bilateral medical orchiectomy with an LHRH agonist (leuprolide acetate) extended median overall survival (OS)...
View ArticleResearch on AS in management of prostate cancer: your input is important!
A diverse group of patients, patient advocates, patient spouses/supporters, physicians, and other researchers has come together, with funding support from the Patient Centered Outcomes Research...
View ArticleThree helpful upcoming webinars
Three upcoming webinars deal with (a) the diagnosis and work-up of clinically significant forms of localized prostate cancer; (b) handling anxiety and related issues for men on active surveillance...
View ArticleAS research survey: your help still needed
As of yesterday, we had already received just under 100 responses to our brief survey on research into active surveillance. However, we would really like to get to something like 250 responses from...
View ArticleHelpful upcoming webinars this week
Three more upcoming webinars this week will deal with (a) the work-up of men with prostate cancer prostate cancer who progress after first-line therapy (such as surgery, radiation, etc.); (b) whether...
View ArticleRethinking risk stratification for radiation therapy
In 2016, we looked at the Candiolo risk stratification system for radiation therapy. To our knowledge, it has not been prospectively validated or widely adopted. In the intervening 5 years, a number of...
View ArticleTiming of initiation of ADT for men with biochemical progression after...
For many years your sitemaster has been advising patients that overly early use of androgen deprivation therapy (ADT) in many men with progressive prostate cancer is not necessarily the best decision...
View ArticleFear of prostate cancer recurrence post-surgery
A new paper by Meissner et al. has reported important, long-term data on fear of recurrence and biochemical progression of prostate cancer among a large cohort of German patients undergoing radical...
View ArticleWhole-pelvic radiation therapy for high-risk patients
The decision about whether or not to treat the entire pelvic lymph node area along with the prostate (called whole pelvic radiation therapy or WPRT) or to treat just the prostate with a margin around...
View ArticleExceptions to “early salvage” radiation treatment for recurrence after...
Three major randomized clinical trials and a meta-analysis have proved that for most men waiting for early signs of recurrence after prostatectomy (e.g., three consecutive PSA rises or a PSA of 0.1...
View ArticleNCCN guidance on the initial management of low-risk, localized prostate cancer
As many readers will already be aware, the National Comprehensive Cancer Network (NCCN) has recently removed the word “preferred” from its statement regarding the use of active surveillance (AS) as an...
View ArticleProjected attendance at AS research conference
About 100 patients, clinicians, and others are already registered as attendees at the conference on Developing Provocative Questions: The Prostate Cancer Active Surveillance Research Initiative Click...
View ArticleNCCN guidance on initial management of low-risk, localized prostate cancer...
In late October, we had commented on the then-latest revision of the National Comprehensive Cancer Network (NCCN)’s guidelines on the initial management of men with low-risk forms of localized prostate...
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